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Zebrafish avatar as a real-time in vivo platform for personalized cancer therapeutics.

Cancer is a leading cause of morbidity and mortality with approx. 35 million people affected by this disease and more than 8 million deaths per year. A major difficulty found in effective cancer treatment is the complexity of the biological mechanism underlying cancer onset and disease progression. This is because the genetic makeup and metabolic profile of each individual patient influence the effect of anticancer drugs. As such, different people respond differently to the same therapy.

The solution we propose in the ZEBRAONCOFISH project is the use of zebrafish avatars as an in vivo platform to guide therapeutic decisions in actionable cancer patient-directed interventions. These avatars will be created by xenotransplantation (interspecies transplant) of human cancer cell lines/ tumor samples in zebrafish. The chance to carry out a dynamic display of the cancerous process in vivo will offer the unique opportunity to understand the subjacent cancer biology and design tailor-made treatments for each patient.

ADVANTAGES

  • Share high molecular and genetic homologies with humans.
  • Large numbers of progeny (important to statistical analysis).
  • Quickly treatment solubilizing news compounds in water.
  • Metastasis in 2 days after transplantation of tumor cells.
  • Easy assessment of drug effects on internal organs using fluorescent labels.
  • Cost effective model.
  • Platform to generate multiple cancer models.
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The ZEBRAONCOFISH study lasts 24 months from September 2017 to August 2019. The project includes cell technology in the development of a novel tool to make cancer care more personalized and effective.